Clopixol/Clopixol-Acuphase/Clopixol Depot Dosage/Direction for Use

Dosage should be individually adjusted according to condition.
Clopixol: In general, small doses should be used initially and increased to the optimal effective level as rapidly as possible based on the therapeutic response.
Acute Schizophrenia and Other Acute Psychoses; Severe Acute States of Agitation; Mania: Oral treatment: Usually 10-50 mg/day. In moderate to severe cases initially 20 mg/day increased, if necessary, by 10-20 mg/day every 2-3 days to ≥75 mg daily.
Chronic Schizophrenia and Other Chronic Psychoses: Oral treatment: Maintenance dosage 20-40 mg/day.
Agitation in Oligophrenic Patients: Oral treatment: 6-20 mg/day, if necessary increased to 25-40 mg daily.
Agitation and Confusion in Senile Patients: Oral treatment: 2-6 mg/day, which can be administered late in the day. If necessary increased to 10-20 mg/day.
Clopixol-Acuphase: Clopixol-Acuphase is administered by IM injection.
The dosage range should normally be 50-150 mg (1-3 mL) IM repeated if necessary, preferably with a time interval of 2-3 days. In a few patients, an additional injection may be needed 24-48 hrs following the 1st injection.
In the maintenance therapy, treatment should be continued with oral Clopixol or Clopixol Depot IM after the following guidelines:
Change to Oral Clopixol: 2-3 days after the last injection of Clopixol-Acuphase, a patient who has been treated with 100 mg Clopixol-Acuphase, oral treatment should be started at a dosage of about 40 mg daily, possibly in divided dosages. If necessary, the dose can be further increased by 10-20 mg every 2-3 days up to 75 mg or more.
Change to Clopixol Depot: Concomitantly with the last injection of Clopixol-Acuphase, a dose of 200-400 mg (1-2 mL) of Clopixol Depot should be given IM and repeated every 2nd week. Higher doses or shorter interval may be needed.
Clopixol Depot: Dosage and interval between injections should be adjusted according to therapeutic response.
Clopixol Depot is administered by IM injection into the upper outer buttock in doses of 200-400 mg at 2- to 4-week intervals. A few patients need higher doses or shorter intervals.
When changing the medication from Clopixol tablet to Clopixol Depot, the following guideline may be used:
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Oral Clopixol should be continued during the 1st week after the 1st injection but in diminishing dosage.